Husbands and Wives Who Smoke Weed Together Don’t Experience the Same High November 11, 2018November 11, 2018 lovingiswhy Blog “Interactions between the endocannabinoid system and the brain level of dopamine—the neurotransmitter of “pleasure” and “reward”—are sex-dependent.” Estradiol seems to be the culprit—a form of estroge…